Read e-book online Advanced Pharmaceutical Solids (Drugs and the Pharmaceutical PDF

By Jens T. Carstensen

ISBN-10: 0585427712

ISBN-13: 9780585427713

ISBN-10: 0824704312

ISBN-13: 9780824704315

Offering present info on crystallization, dissolution from debris and polydisperse populations, powder volumes and densities, comminution, rainy granulation, and hard-shell pills, complex Pharmaceutical Solids, describes moisture isotherms with crystalline solids, files the results of moisture on solid-state balance, highlights capsule physics and rules, explains sustained unencumber through microencapsulation, offers prediction equations for solubility in binary solvents, discusses particle sizes and diameters, identifies Brunauer, Emmett, and Teller Isotherms and extra! contemplating houses of solids, permeamitry and fuel absorption tools, amorphates, and purification through pH-change precipitation, complicated Pharmaceutical Solids is an important reference for pharmacists pharmaceutical scientists medicinal, actual, floor, colloid, and analytical chemists and biochemists and a good textual content for upper-level undergraduate and graduate scholars in those disciplines.

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Additional resources for Advanced Pharmaceutical Solids (Drugs and the Pharmaceutical Sciences)

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Drug substances maycomplexwithcomplexing agents. An exampleis ascorbic acid/niacinamide (niacinamide ascorbate). , drug A)? is called the substrate and the other ligand. A drug A (the substrate) will react with another compound I3 (the ligand) and form a weak e ~ u i l i b r i u ~ . 21) K =[ ~ ~ l / [ ~ ~ [ ~ l The concentration of u n c o ~ p l e ~ substrate ed is the solubility when no ligand is present. [A] = S The ~uantitiesin brackets are actual concentrations in the complexed system. If, by , we denote the concentration of ligand calculated based on the t the amount complexed.

4) should read: B is the triple point between triclinic, monoclinic and vapor; D is the triple point between triclinic, liquid, and vapor. ) They found the transition point by using a tube heated at the position of the solid, and by monitor in^ the deposit and the temperature alongthe tube; they found that 132 was the triple point. -F, Agafonov VN, Dzyabchen~oAV, Bachet B (1997). J Pharm Sci 86:1062. Einstein A (1907). Ann Physik 22: 180. Grant DJW, York P (1986). Int J P h a m 30:161. Hersey JA, Krycer I (1981).

Debye later refined the model to include many frequencies and obtained an even better fit. The important lesson to draw from this is that heat ca~acitiesare ( ~ e ~ eonn ~ i ~ ~ the c o m ~ o u ~ dat) times s u f ~ c i e n t ltewlperature-dependent ~ and thatthis ~ h o ~ be ld taken into account. 39) ~l uses this, and higher polynomial For instance, ~ n t e ~ n a t i o n a l~ r i t i cTables ap~roximations,when tabulating heat capacities and enthalpies as a function of te~perature. 0 iarnond heat capacities compared with the Einstein.

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Advanced Pharmaceutical Solids (Drugs and the Pharmaceutical Sciences) by Jens T. Carstensen

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